ascR [2017-8-11 16:0:3]

alkyl-sulphur catabolism regulator, transcriptional activator of the snaA-tcyJ-tcyK-tcyL-tcyM-tcyN-cmoO-cmoI-cmoJ-ribR-sndA-ytnM operon

locus: BSU29400

pI: 6.23

mw: 35.08 kDa

protein length: 308 aa

gene length: 924 bp

function: regulation of sulphur metabolism

product: alkyl-sulphur catabolism regulator, transcriptional activator (LysR family)

essential: no

synonyms: ytlI

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.9|Biosynthesis/ acquisition of cysteine]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.4|Sulfur metabolism] → [category|SW 2.6.4.1|Conversion of S-methyl cysteine to cysteine]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]

Gene

Coordinates: 3,008,938 → 3,009,864

The protein

Protein family

• [SW|LysR family]

Expression and Regulation

Operons

• genes: [gene|741156D495BE3857683C8A0390764EAD83845ABC|ascR]
  description: [Pubmed|9387221]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|16109943], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [protein|50930C56C27D22715620A350220E3C56ADB41020|CymR]: repression, [Pubmed|16109943], in [regulon|50930C56C27D22715620A350220E3C56ADB41020|CymR regulon]

  regulation

  • repressed in the presence of cysteine ([protein|search|CymR]) [Pubmed|16109943]

Biological materials

Mutant

• MGNA-A169 (ytlI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/169 NBRP B. subtilis, Japan]

References

• 15937167,11390694,16109943,16513748,9387221,16109943,23944997